Pulmonary embolism (PE) is one of the most challenging respiratory emergencies EMS providers encounter. Patients often present with nonspecific symptoms and relatively normal lung sounds, but their condition can rapidly progress to hemodynamic collapse if left untreated.
Because definitive diagnosis requires hospital-based imaging and testing, prehospital providers must rely on assessment findings, patient history, and clinical suspicion. Recognizing the possibility of PE early can help ensure appropriate treatment, transport decisions, and communication with receiving facilities.
What Is a Pulmonary Embolism?
PE occurs when a clot or other obstruction blocks blood flow within the pulmonary circulation. Most pulmonary emboli originate as deep vein thromboses (DVTs) in the lower extremities before traveling to the lungs.
Once lodged in a pulmonary artery, the clot prevents blood from reaching portions of the lung for oxygen exchange. Although ventilation may remain intact, perfusion becomes impaired. This creates a ventilation-perfusion mismatch that reduces oxygen delivery throughout the body.
The severity of symptoms depends on the size and location of the obstruction. Small emboli may cause mild shortness of breath, while massive pulmonary emboli can lead to shock, cardiac arrest, or sudden death.
Why PE is Often Missed
Many respiratory emergencies produce similar complaints. Patients with asthma, pneumonia, heart failure, anxiety, or PE may all report shortness of breath and chest discomfort. Unlike pneumonia or pulmonary edema, PE frequently produces few abnormal lung findings. Providers may hear clear breath sounds despite significant hypoxia and respiratory distress.
This disconnect between patient appearance and lung auscultation should raise suspicion. When a patient appears critically ill, but lung sounds do not explain the severity of symptoms, providers should consider PE as part of their differential diagnosis.
Identifying High-Risk Patients
Patient history often provides the strongest clues. Recent surgery, prolonged immobility, hospitalization, active cancer, pregnancy, and hormonal therapy can all increase the risk of clot formation. Long-distance travel, particularly flights lasting several hours, may also contribute to venous thromboembolism. Patients with a history of DVT or prior PE remain at elevated risk for recurrence.
In many cases, patients describe a sudden onset of symptoms. They may report feeling normal earlier in the day before developing abrupt shortness of breath, chest pain, dizziness, or weakness.
Common Assessment Findings
Although presentations vary, PE often produces a recognizable pattern. Patients frequently exhibit tachypnea, tachycardia, hypoxia, and signs of increased work of breathing. Some report pleuritic chest pain that worsens with deep inspiration. Others complain primarily of unexplained shortness of breath.
As the obstruction becomes larger, signs of right-sided heart strain may develop. Patients can become hypotensive, diaphoretic, altered, or increasingly unstable. In severe cases, pulseless electrical activity (PEA) may be the first indication of a massive PE.
Massive vs. Submassive PE
Not all pulmonary emboli present the same way. Smaller emboli may cause respiratory symptoms while preserving blood pressure and overall perfusion. These patients often remain stable during transport.
Massive pulmonary emboli create significant obstruction within the pulmonary circulation, increasing pressure on the right ventricle and reducing cardiac output. These patients may develop hypotension, shock, altered mental status, or cardiac arrest.
Recognizing signs of hemodynamic instability is critical because deterioration can occur rapidly.
EMS Treatment Priorities
Prehospital treatment focuses on supporting oxygenation, monitoring for deterioration, and transporting the patient to definitive care. Supplemental oxygen should be administered as needed to maintain adequate oxygen saturation. Continuous ECG monitoring can help identify tachycardia and other signs of cardiovascular compromise. Frequent reassessment is essential because patients may worsen quickly.
Although EMS providers cannot remove the clot in the field, early recognition allows receiving facilities to prepare for advanced interventions such as anticoagulation, catheter-directed therapies, or thrombolytic treatment.
Looking Beyond Lung Sounds
PE highlights the importance of evaluating the entire patient rather than focusing on a single assessment finding. A patient with severe respiratory distress and clear lungs should never be dismissed as having a minor complaint. Instead, providers should consider the patient’s history, risk factors, symptom onset, and overall presentation.
Strong clinical suspicion is one of the most valuable tools EMS providers have when identifying PE in the field. By recognizing the warning signs early, clinicians can improve communication, accelerate definitive treatment, improve outcomes, and save lives.
MORE FROM IMPACT EMS TRAINING:
- Subscribe to Impact in Action to complete your Live CE license renewal requirements through interactive, case based learning led by experienced EMS professionals.
- Advance your scope with Impact’s certification, refresher, test prep, and critical care courses.
- Review the Impact EMS Training Weekly EMS Blog.
- Stay up to date with Impact EMS Training’s Events Calendar.
- Is your recert date coming up? Reference your state’s CE and license renewal requirements.


